Dynamic Combinatorial Chemistry and Virtual Combinatorial Libraries
Identifieur interne : 000463 ( Main/Exploration ); précédent : 000462; suivant : 000464Dynamic Combinatorial Chemistry and Virtual Combinatorial Libraries
Auteurs : Jean-Marie Lehn [France]Source :
- Chemistry – A European Journal [ 0947-6539 ] ; 1999-09-03.
English descriptors
- Teeft :
- Active substances, Angew, Basic components, Basic features, Building blocks, Chem, Combinatorial, Combinatorial approach, Combinatorial chemistry, Combinatorial features, Combinatorial libraries, Combinatorial library, Constituent, Coordination chemistry, Different components, Dynamic combinatorial, Dynamic combinatorial chemistry, Dynamic combinatorial materials, Dynamic diversity, Dynamic generation, Dynamic library, Dynamic materials, Environmental factors, Fluxional changes, Functional groups, Gmbh, Interactional features, Large number, Lehn, Materials science, Metal ions, Novel materials, Other areas, Other hand, Photodynamic combinatorial processes, Physical properties, Polymer, Possible combinations, Possible constituents, Present combinatorial libraries, Recent reports, Receptor, Recognition processes, Reversible, Reversible combination, Reversible connection, Reversible connections, Reversible reactions, Reversible recombination, Search procedure, Signal transduction, Special issue, Strong inhibitor, Strongest interaction, Supramolecular, Supramolecular materials, Supramolecular polymer chemistry, Supramolecular polymers, Target site, Tetrahedron lett, Unpublished work, Vcls, Verlag, Verlag gmbh, Virtual, Virtual combinatorial libraries, Weinheim.
Abstract
The reversible connection between sets of basic components allows the generation of a large collection of compounds constituted by all possible combinations that are potentially available. It makes virtual combinatorial libraries of substances accessible through a dynamic approach to combinatorial chemistry. The thermodynamically‐driven evolution of the system leads to the actual expression of the constituent(s) that present(s) the best binding to/molecular recognition with the target site (see diagram). The general concept of this methodology has wide applications in a variety of areas of science and technology.
Url:
DOI: 10.1002/(SICI)1521-3765(19990903)5:9<2455::AID-CHEM2455>3.0.CO;2-H
Affiliations:
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Le document en format XML
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